Prebiotics as a Means to Modulate Gut Fermentation, Metabolism, Appetite and Cognition

Lund University

Status and phase: Completed; Early Phase 1

Conditions: Metabolic Syndrome

Treatments: Other: reference meal; Other: test meal

Study type: Interventional

Funder types: Other

Identifiers

NCT01718431

Dnr2010/457 - 3day

Details and patient eligibility

About

This study aims at investigating the impact of colonic fermentation of intrinsic indigestible carbohydrates in cereal whole kernels after three days consumption, on metabolic variables and cognition. The study is performed in healthy, normal to slightly over-weight test subjects.

Enrollment: 40 patients

Sex: All

Ages: 50 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• BMI 19-28 kg/m2

Exclusion criteria

• gastrointestinal diseases
• metabolic disorders
• tobacco/snuff user
• antibiotic/probiotic treatment

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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40 participants in 2 patient groups

indigestible carbohydrates

Experimental group

Description:

test meal: indigestible carbohydrates

Treatment:

Other: test meal

reference

Experimental group

Description:

reference meal: no indigestible carbohydrates

Treatment:

Other: reference meal