Precise Treatment System of Biliary Malignancies Based on Special Disease Database

Shanghai Jiao Tong University

Status: Unknown

Conditions: Gall Bladder Carcinoma; Biliary System Disorder; Cholangiocarcinoma

Study type: Observational

Funder types: Other

Identifiers

NCT03499782

XHEC-JDYXY-2018-002

Details and patient eligibility

About

Malignant tumors of biliary system lack standard treatment and precise prognosis assessment methods. This study including 12 hospitals, collecting clinical and follow-up data of patients with biliary malignant tumors including cholangiocarcinoma and gallbladder carcinoma in recent 10 years, aim to build a special disease database, then use Bayesian networks and importance theory to establish a mathematical model to assess treatment strategies and prognosis accurately. At the same time, data on biliary malignant tumors newly treated by multicenters from 2018 to 2020 will be included to validate, adjust and refine the models to guide clinical individualized precise treatment.

Enrollment: 10,000 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria：

• Clinical diagnosis of biliary malignancy including gallbladder carcinoma or cholangiocarcinoma verified by pathological results
• Must be able to undergo surgery
• Undergoing radical surgery for biliary malignancy (R0 or R1 resection)
• Not complicated with other malignancy
• No other treatments before and during surgery, such as radiotherapy and chemotherapy.

Exclusion Criteria:

• Non-primary gallbladder or cholangiocarcinoma
• With distant metastasis (M1 phase)
• Incomplete follow-up data
• Died within 30 days after surgery.