Precision Allergy: Separate Allergies to Male and Female Dogs

Copenhagen Studies on Asthma in Childhood

Status: Completed

Conditions: Allergy; Dander

Treatments: Diagnostic Test: Male dog; Diagnostic Test: Female dog

Study type: Interventional

Funder types: Other

Identifiers

NCT03097094

Dog allergy

Details and patient eligibility

About

A new male-specific dog-allergen-component has been found (Can f 5) which indicates possible differences in allergic reactions to male and female dogs. This has not yet been tested in real life.

The aim is to test if sensitization only to the male-dog specific allergen-component, Can f 5, results in a positive skin prick test (SPT) to male dog extract and not female dog extract. In addition, the investigators want to investigate if allergic symptoms only occur when exposed to the male dog extract by conjunctival provocation.

Enrollment: 22 patients

Sex: All

Ages: 15+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Participants in the COPSAC 2000 cohort
• Positive component test (>0.3 ISU) to Can f 1, Can f 2, Can f 3 or Can f 5

Exclusion criteria

• Uncontrolled asthma
• Eye-surgery within the past 6 months
• Antihistamine allergy
• and others

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

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22 participants in 2 patient groups

Male dog

Active Comparator group

Description:

Male dog extract used for skin prick test and conjunctival provocation

Treatment:

Diagnostic Test: Male dog

Female dog

Active Comparator group

Description:

Female dog extract used for skin prick test and conjunctival provocation

Treatment:

Diagnostic Test: Female dog