Precision Dietary Intervention Improves Postoperative Energy Intake, Nutritional Status, and Recovery in Patients Undergoing Hepatectomy for Liver Cancer: A Randomized Controlled Trial

University of Science and Technology of China (USTC)

Status

Completed

Conditions

Primary Liver Cancer

Treatments

Other: Conventional dietary intervention

Dietary Supplement: Special diet plan and whole protein preparation NUTRICIA for 5 days after liver resection for liver cancer

Study type

Interventional

Funder types

Other

Identifiers

NCT07349576

2024KY-013

Details and patient eligibility

About

Objective:To explore the application effect of postoperative refined early dietary plan in the enhanced recovery of patients undergoing hepatectomy for primary liver cancer, and to provide scientific evidence for optimizing postoperative dietary structure and increasing oral energy intake of patients.

Methods:In this randomized, parallel-controlled trial, 142 colorectal cancer survivors meeting inclusion criteria were recruited from a tertiary hospital in Hefei, Anhui Province. Participants were randomly assigned in a 1:1 ratio to either the dietary intervention group or the conventional diet group. Both the standard care group and the dietary intervention group received 5 days of routine dietary care. The dietary intervention group additionally received specialized meal plans and whole protein supplements beyond the standard care regimen. Dietary intake, nutritional status, and postoperative recovery outcomes were measured and compared between the two groups.

Enrollment

139 patients

Sex

All

Ages

18 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

(1) Pathologically confirmed diagnosis of primary hepatocellular carcinoma; (2) Underwent elective (partial) hepatectomy; (3) Age 18-80 years; (4) Basically normal renal function and preoperative Child-Pugh liver function grade A or B; (5) Voluntary participation in the study and signed informed consent.

Exclusion criteria

(1) Concurrent malignant tumors; (2) Postoperative deterioration or contraindications to oral intake (e.g., dysphagia, intestinal obstruction); (3) Severe malnutrition or other disorders affecting nutritional metabolism; (4) Major intraoperative complications (e.g., massive hemorrhage, bile leakage, intra-abdominal adhesions); (5) Postoperative transfer to the ICU.