PRecIsion Medicine in CardiomyopathY (PRIMaCY)

T

The Hospital for Sick Children

Status

Active, not recruiting

Conditions

Sudden Cardiac Death

Hypertrophic Cardiomyopathy

Study type

Observational

Funder types

Other

Identifiers

NCT04036799

1000055819

Details and patient eligibility

About

This is a retrospective cohort study of pediatric hypertrophic cardiomyopathy (HCM) patients using chart and registry review methodology. The studies objective is to develop and validate a sudden cardiac death (SCD) risk calculator that is age-appropriate for children with HCM that includes clinical and genetic factors.

Enrollment

572 patients

Sex

All

Ages

Under 18 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

phenotype-positive patients diagnosed with hypertrophic cardiomyopathy
phenotype-negative, genotype positive patients considered at risk for developing hypertrophic cardiomyopathy

Exclusion criteria

Neuromuscular, metabolic, syndromic (other than Noonan Syndrome and related RAS-opathies) or endocrine (including infants of diabetic mothers) causes of HCM
(Other treatable causes of left ventricular hypertrophy (systemic hypertension, anatomic defects causing left ventricular outflow tract obstruction e.g. aortic stenosis, subAS, subaortic membrane, coarctation)