Precision Nutrition Recommendations Generated by Metataxonomic Microbiome Testing Improve Food Group Choices and Intestinal Health Indicators in an Obese Population in Colombia

Astrolab bio

Status: Completed

Conditions: Obesity & Overweight; Gut; Microbiome

Treatments: Other: Personalized dietary recommendations

Study type: Interventional

Funder types: Industry; Other

Identifiers

NCT07492485

03-89-1109- 2012

Details and patient eligibility

About

This study evaluated whether personalized dietary recommendations based on gut microbiome testing can improve intestinal health and food choices in adults with obesity in the region of Antioquia, Colombia. Fifty participants were randomly assigned to an intervention or control group. Outcomes included gut microbiome composition, blood biomarkers, weight, physical activity frequency, and dietary adherence over 12 weeks

Full description

The study investigated the effects of precision nutrition recommendations on gut microbiota diversity and metabolic health in obese adults. Fifty participants (BMI ≥30) affiliated with Comfama healthcare in Antioquia, Colombia, were randomized into an intervention group (n=25) receiving a 12-week diet plan designed to improve microbial diversity and metabolic health, and a control group (n=25).

The intervention emphasized increased fiber intake, fermented foods, reduced sugar and saturated fats, and a variety of colorful fruits and vegetables. Probiotic or prebiotic supplements were included in selected cases. Outcomes were measured at baseline and after 12 weeks and included gut microbiota diversity via 16S rRNA gene sequencing (V3-V4 region), blood biomarkers (HbA1c, total cholesterol, HDL, LDL, triglycerides, glucose), anthropometric data, dietary adherence, physical activity, and psychological measures. Significant improvements in microbial diversity and intestinal health indicators were observed in the intervention group.

Enrollment: 50 patients

Sex: All

Ages: 23 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Affiliation with Comfama healthcare provider
• Age between 23 and 65 years
• Body Mass Index (BMI) ≥ 30 kg/m²
• Residence in Medellín, Antioquia, Colombia
• Willingness and ability to participate in the study for 12 weeks

Exclusion criteria

• Pregnancy or lactation
• History of bariatric surgery
• Diagnosed mental health conditions
• Use of specific medications (e.g., antidepressants, antibiotics)
• Participation in a structured nutritional plan
• Planned extended travel within the next 9 months

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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50 participants in 2 patient groups

Control Group

No Intervention group

Experimental Group

Experimental group

Treatment:

Other: Personalized dietary recommendations