Precision Pain Management for Major Abdominal Surgery in Colorectal Surgery (PPaM)

NeuroTherapia, Inc.

Status

Terminated

Conditions

Diverticular Disease

Ulcerative Colitis

Crohn Disease

Colorectal Cancer

Treatments

Genetic: PGx-guided post-operative pain management

Study type

Interventional

Funder types

Other

Identifiers

NCT03455751

17-1540

Details and patient eligibility

About

The primary objectives of this study are to evaluate the potential for preoperative pharmacogenomics (PGx) testing to positively influence postoperative opioid use through visual analog scale (VAS) guided administration of narcotic equivalent and lower pain scores as measured by OBAS in patients undergoing major abdominal surgery.

Enrollment

10 patients

Sex

All

Ages

18 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Subject capable of giving consent
Age 18-80
Scheduled for open colorectal resection at Cleveland Clinic main campus (with preoperative appointment scheduled at least five days before date of surgery)

Exclusion criteria

Patient does not speak English
Patient with substance-use disorder (including alcohol)
Patient diagnosed with major depression
Patient currently taking opioids
Previous long-term opioid use (> 3 months)
Previous opioid use with a dose of >100 milligram morphine equivalent (MME)
Patient has pain-related disorder (e.g. fibromyalgia, sympathetic dystrophy, etc.)
Documented allergy to pain medication