Preclinical Brain Tumor Models (HITCH)

Public Assistance-Hospitals of Marseille (AP-HM)

Status: Enrolling

Conditions: Brain Metastases; Diffuse Gliomas

Treatments: Other: Fresh tumor sampling

Study type: Observational

Funder types: Other

Identifiers

NCT06045065

RCAPHM20_0037 - HITCH

Details and patient eligibility

About

Background: Primary or secondary brain tumors (metastases) remain associated with a very poor prognosis linked to significant therapeutic resistance. Thus, glioblastoma, which is the most common and aggressive primary brain tumor in adults, is associated with inevitable relapses within 7 to 10 months and median survival of approximately 12 to 14 months. At the same time, brain metastases are increasingly increasing following better systemic control of other metastatic sites and improvement in detection methods. However, they remain resistant to the latest therapeutic innovations such as immunotherapies or targeted therapies.

In this context, innovative strategies are necessary to identify new therapeutic targets and implement new treatments to overcome resistance phenomena in the clinic.

Objective: Our goal will be to generate tumoroids and stem-like cell lines (PDX) from patient tumor samples.

Methods: We will establish tumor tumoroids and stem cell lines from patient samples. These preclinical models will allow us to test a large number of drugs, quickly and efficiently thanks to models as close as possible to patient tumors and limiting the use of animal models (3R).

Overall, this project should enable major advances in the treatment of glioblastoma and brain metastases and enable the rapid testing of new molecules in clinical trials thanks to the homology of our models with our patients' diseases.

Enrollment: 60 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult patients
• Brain tumor neuro-imaging
• Eligible for neurosurgery

Exclusion criteria

• unresectable tumor

Trial design

60 participants in 2 patient groups

patients with primitive tumor

Description:

Patient samples will be collected during routine care neurosurgical resection.

Treatment:

Other: Fresh tumor sampling

patients with brain metastasis

Description:

Patient samples will be collected during routine care neurosurgical resection.

Treatment:

Other: Fresh tumor sampling