Preclinical Cardiomyopathy and Autonomic Function in Type 1 Diabetes

Roberto Léo da Silva

Status: Completed

Conditions: Diabetes Mellitus, Type 1; Diabetic Cardiomyopathies; Autonomic Neuropathy, Diabetic

Study type: Observational

Funder types: Other

Identifiers

NCT03930004

HU-UFSC 2018

Details and patient eligibility

About

Type 1 diabetes mellitus is a chronic autoimmune disease, associated with an increased risk of cardiovascular diseases. The development of cardiomyopathy in type 1 diabetes, independent of hypertension and coronary heart disease, is still controversial. A possible mechanism for diabetic cardiomyopathy is autonomic dysfunction. This study aims to evaluate cardiac function and structure, and to relate them with autonomic dysfunction in type 1 diabetes.

Enrollment: 80 patients

Sex: All

Ages: 20 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• type 1 diabetes mellitus

Exclusion criteria

• hypertension
• coronary artery disease
• heart valve disease
• ventricular dysfunction
• radiotherapy or chemotherapy
• alcoholism
• limited acoustic window

Trial design

80 participants in 2 patient groups

Type 1 diabetic patients

Description:

Patients diagnosed with type 1 diabetes mellitus with criteria for cardiovascular autonomic neuropathy, asymptomatic, normotensive, with negative medical history of cardiovascular disease. Transthoracic echocardiography, including: tissue Doppler indices of diastolic filling and speckle tracking for systolic and diastolic strain/strain rate, exclusion of valvular abnormalities, assessment of heart structure and function.

Control - Healthy subjects

Description:

Fifteen age- and sex-matched healthy control subjects, asymptomatic, normotensive, with negative medical history of cardiovascular disease. Transthoracic echocardiography, including: tissue Doppler indices of diastolic filling and speckle tracking for systolic and diastolic strain/strain rate, exclusion of valvular abnormalities, assessment of heart structure and function.