Preclinical Research for Personalized TCR-T Therapy for Head and Neck Cancer

Eye & ENT Hospital of Fudan University

Status: Enrolling

Conditions: Head and Neck Cancer

Treatments: Other: No intervention

Study type: Observational

Funder types: Other

Identifiers

NCT05697926

2022105

Details and patient eligibility

About

This study will obtain tumor samples from patients with head and neck cancers and aims to develop personalized TCR-T therapy for head and neck cancer by determining the reactive TCR clone sequences in head and neck cancer.

Enrollment: 100 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Gender is not limited, age 18-75 years old;
2. Estimated survival is greater than 3 months;
3. Newly diagnosed patients with head and neck cancer without any treatment, or patients with refractory recurrent advanced head and neck cancer for which there is no available effective treatment;
4. Patients with head and neck cancer whose tumor tissue can be surgically harvested;
5. Volunteer to join the study and sign the informed consent.

Exclusion criteria

1. Infected or had been infected with COVID-19;

2. Active hepatitis B or C virus, HIV infection, or other uncured active infected persons;

3. Patients with head and neck cancer who had received the following treatments:

   The patient had a history of using PD-1 and other immune checkpoint inhibitors 8 weeks before surgery; History of chemotherapy drug use 8 weeks before surgery; A history of hormone drug use within 4 weeks before surgery;

4. Other situations that are not appropriate to be included in the clinical trial.

Trial design

100 participants in 1 patient group

Experiment

Description:

The excess tumor tissue from patients following surgical resection will be collected for further analysis.

Treatment:

Other: No intervention