Preconditioning of One-lung Ventilation

Seoul National University

Status: Completed

Conditions: One Lung Ventilation

Treatments: Other: One-lung ventilation

Study type: Interventional

Funder types: Other

Identifiers

NCT03282032

JHSeo_preconditioning

Details and patient eligibility

About

To observe the effect of one-lung ventilation (OLV) preconditioning on perioperative oxygenation during thoracic surgery.

Full description

For lung isolation and better surgical view, one-lung ventilation(OLV) is essential for thoracic surgery. However, OLV may cause serious pulmonary complications due to intraoperative hypoxia.

Animal studies showed a positive effect of OLV preconditioning (Intermittent OLV before surgical intervention) on perioperative pulmonary oxygenation.

Thus, we designed a study to observe the effect of OLV preconditioning on perioperative oxygenation during thoracic surgery

Enrollment: 136 patients

Sex: All

Ages: 20 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Elective thoracic surgery which requires one-lung ventilation with lateral decubitus position

Exclusion criteria

• Patients with severe cardiopulmonary disease, COPD, previous surgical history of pulmonary disease
• Thoracic surgery for pneumonectomy

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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136 participants in 2 patient groups

One-lung ventilation

Experimental group

Description:

Before surgical incision, 2-min of OLV followed by 2-min of TLV (1 cycle) is performed for 5 cycles.

Treatment:

Other: One-lung ventilation

Two-lung ventilation

No Intervention group

Description:

Maintain two-lung ventilation until surgical incision