Preconditioning With Hyperbaric Oxygen in Cardiovascular Surgery

Air Force Military Medical University of People's Liberation Army

Status: Completed

Conditions: Brain Injury; Myocardial Injury

Treatments: Device: Hyperbaric oxygen pretreatment (GR2200)

Study type: Interventional

Funder types: Other

Identifiers

NCT00817791

liyang2007

Details and patient eligibility

About

Animal studies have shown that preconditioning with hyperbaric oxygen can induce central nervous system and heart ischemic tolerance. This study was designed to determine the protective effect of hyperbaric oxygen preconditioning on brain and myocardium ischemia-reperfusion injury during coronary artery bypass graft surgery.

Full description

60 patients scheduled to undergo coronary revascularization were recruited for this trial. Exclusion criteria included Emergency operation, age older than 80 years, learning difficulty, previous cerebrovascular disease, visual or hearing impairment, history of pneumothorax, Claustrophobia, middle ear disease, EF < 35%. Patients were randomized either to the control group or hyperbaric oxygen group. The laboratory analysis of markers included S100B, NSE and troponin I. The assessment of cognitive dysfunction was performed 5 days before surgery and 7 days after surgery and haemodynamic measurements, length of stay in ICU, length of stay in hospital post-operation were recorded.

Enrollment: 49 patients

Sex: Male

Ages: Under 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients scheduled to undergo coronary revascularization surgery.

Exclusion criteria

• Emergency operation
• Age older than 80 years
• Learning difficulty
• Previous cerebrovascular disease
• Visual or hearing impairment
• History of pneumothorax, claustrophobia, middle ear disease, EF < 35%

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

---

49 participants in 1 patient group

HBO

Experimental group

Treatment:

Device: Hyperbaric oxygen pretreatment (GR2200)