PREdelivery Placental Biomarkers- Pregnancy and Delivery Outcome (PREPPeD)

University of Oslo (UIO)

Status: Unknown

Conditions: Pregnancy Complications; Placental Insufficiency

Treatments: Other: Blood sampling

Study type: Observational

Funder types: Other

Identifiers

NCT03100084

36864

36259 (Other Identifier)

Details and patient eligibility

About

The PREPPeD study proposes that predelivery placenta-derived maternal circulating biomarkers reflect placental health, capacity and ageing, and can help predict onset and complications of delivery both in complicated pregnancies as well as in clinically uncomplicated term/post-term pregnancies.

Full description

The main aim of the PREPPeD study is to explore whether placental health, evaluated by maternal blood biomarkers in late pregnancy, correlates with delivery outcomes in both healthy and complicated pregnancies.

Enrollment: 1,000 estimated patients

Sex: Female

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• All pregnant women scheduled to deliver at the Department of Obstetrics at OUH who qualify for the study groups as specified in the "Groups and Intervention" section.

Exclusion criteria

• Women who do not understand Norwegian or English
• Communicable disease
• Younger than 18 years of age
• Legally incompetent
• Fetal malformations

Trial design

1,000 participants in 7 patient groups

I. Post Dates

Description:

Pregnant women referred for clinical post term evaluation and/or labour induction. Blood sampling.

Treatment:

Other: Blood sampling

II. Induction of Labour

Description:

Pregnant women ≥37+0 GW (gestational week) referred for labour induction (any cause). Blood sampling.

Treatment:

Other: Blood sampling

III. All Outpatients

Description:

Pregnant women ≥37+0 GW presenting for any medical reason at OUH outpatient clinic. Blood sampling

Treatment:

Other: Blood sampling

IV. Diabetes in Pregnancy

Description:

Pregnant women ≥36+0 GW with pregestational or gestational diabetes. Blood sampling.

Treatment:

Other: Blood sampling

V. Reduced Fetal Movements

Description:

Pregnant women ≥37+0 GW with reduced fetal movements and/or referred due to reduced symphysis-fundal height. Blood sampling.

Treatment:

Other: Blood sampling

VI. Hypertensive Disorders in Pregnancy

Description:

Pregnant women referred for preeclampsia (or other pregnancy induced hypertensive disorders) and/or suspected fetal growth restriction; longitudinal cohorts. Blood sampling.

Treatment:

Other: Blood sampling

VII. All Labour Admissions

Description:

All pregnant women ≥37+0 GW admitted for labour. Blood sampling.

Treatment:

Other: Blood sampling