Prediabetes, Exercise, and Appetite Regulation (PEAR)

Utah System of Higher Education (USHE)

Status: Terminated

Conditions: Appetitive Behavior; PreDiabetes

Treatments: Behavioral: Resistance Exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT04910763

000116248

Details and patient eligibility

About

The purpose of the study is to learn about how type of exercise influences measures of appetite regulation.

Full description

The primary objective of this study is to understand the relationship between exercise modality and appetite regulation in a population with pre-diabetes. The study includes a screening visit to ensure eligibility of participants, baseline assessments, a resistance exercise intervention, and post intervention measurements. The variables of interest include, but are not limited to, hormonal responses to exercise training pertaining to appetite, food cravings, appetite ratings. activity levels, body composition, and ten repetition-max strength. The aim of this study is to better understand the mechanisms involved in the correlation or causation of any improvements in fitness and appetite regulation in a cohort with pre-diabetes.

Enrollment: 23 patients

Sex: All

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age 18-50 years of age
• BMI between 27-40 kg/m²
• Hemoglobin A1c level between 5.7% and 6.4%
• Physical Activity (less than 150 min/week moderate-intensity Physical Activity, no more than 1 session/week of resistance exercise)

Exclusion criteria

• Unstable Cardiovascular Disease
• Uncontrolled hypertension
• Severe hypertriglyceridemia
• History of or active liver disease
• Uncontrolled thyroid disease
• Active cancer diagnosis
• Smoking
• Engaged in exercise or diet program
• History of bariatric surgery
• GI malabsorptive disorders
• Significant diet intolerances
• History of major psychiatric disorder
• presence of alcohol or substance abuse;
• medications affecting weight,
• EI or EE in past 6 months;
• women currently pregnant, lactating, less than 6 months post-partum, or postmenopausal.

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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23 participants in 1 patient group

Resistance Exercise

Experimental group

Description:

Resistance exercise will be training all major muscle groups 2x/week (2 days upper body, 2 days lower body) at 40-50% 1 repetition max (RM; estimated from 10 RM baseline testing) for 3 sets of 10-12 reps. This equals 4x/week for the 3 week intervention period.

Treatment:

Behavioral: Resistance Exercise