Predictability of the Pulse Pressure Variation (PPV) During Spontaneous Ventilation on the Incidence of Hypotension During Induction of Anesthesia

Seoul National University

Status: Unknown

Conditions: Hypotension

Treatments: Drug: Volume loading; Other: PPV<14%; Other: PPV>14%

Study type: Interventional

Funder types: Other

Identifiers

NCT02208570

JHBahk_PPV_predictability

Details and patient eligibility

About

The purpose of this study is to find out the predictability of the pulse pressure variation during spontaneous ventilation on the incidence of hypotension during induction of anesthesia.

Enrollment: 172 estimated patients

Sex: All

Ages: 20 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients undergoing general anesthesia induction with intravenous anesthesia using propofol and remifentanil
• Patients requiring invasive arterial blood pressure monitoring for the surgery

Exclusion criteria

• Refusal of consent
• Patients with heart disease (symptomatic valvular heart disease, intracardiac shunt, pulmonary hypertension with pulmonary systolic arterial pressure exceeding 40mmHg)
• FEV1 ≤ 50% predicted FEV1
• Patients with chronic renal failure
• ASA class IV, V, VI
• Systolic arterial blood pressure below 90mmHg before induction of anesthesia

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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172 participants in 4 patient groups

P(+)V(+)

Experimental group

Description:

PPV\>14% before anesthesia induction, HES 6ml/kg infused

Treatment:

Other: PPV>14%

Drug: Volume loading

P(+)V(-)

Experimental group

Description:

PPV\>14% before anesthesia induction, no additional volume infused

Treatment:

Other: PPV>14%

P(-)V(+)

Experimental group

Description:

PPV\<14% before anesthesia induction, HES 6ml/kg infused

Treatment:

Drug: Volume loading

Other: PPV<14%

P(-)V(-)

Experimental group

Description:

PPV\<14% before anesthesia induction, no additional volume infused

Treatment:

Other: PPV<14%