Predicting Bispectral Index Values by Estimated Effect-site Concentration of Propofol and Remifentanil Displayed on the Target-centered Infusion Pump

Samsung Medical Center

Status: Unknown

Conditions: Total Intravenous Anesthesia; Bispectral Index Monitoring; General Anesthesia

Study type: Observational

Funder types: Other

Identifiers

NCT01604226

2012-04-094

Details and patient eligibility

About

The BIS is influenced by multiple parameters, such as age,gender, body weight, height, muscle relaxants, hepatic function, co-administered drugs, surgical stimulation, but is thought to be influenced mainly by propofol and remifentanil infusion dose. As such, the investigators postulate that the BIS value could be predicted by the estimated effects-site concentration of propofol and remifentanil, and try to establish a multiple linear regression model for predicting BIS value.

Full description

Total intravenous anesthesia is commonly performed with propofol and remifentanil now-a-days. The combination of these two drugs can achieve the rapid loss of consciousness and analgesia,as the onset and recovery time of these two drugs are very fast within one to three minutes. However, the problem of intraoperative awareness necessitate the monitoring of anesthetic depth, which is commonly performed with Bispectral index (BIS). BIS is a display of number from zero to one hundred which quantify the degree of sedation and hypnosis by anesthetics by analyzing the electroencephalogram. However, it is limited in neurosurgery in which the surgical field is near the forehead where the BIS probe is attached. Furthermore, it is also limited in surgery with prone position. The BIS is influenced by multiple parameters, such as age,gender, body weight, height, muscle relaxants, hepatic function, co-administered drugs, surgical stimulation, but is thought to be influenced mainly by propofol and remifentanil infusion dose. As such, we postulate that the BIS value could be predicted by the estimated effects-site concentration of propofol and remifentanil, and try to establish a multiple linear regression model for predicting BIS value.

Enrollment: 100 estimated patients

Sex: All

Ages: 20 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Those undergoing gynecologic or urologic surgery with general anesthesia with total intravenous anesthesia
• Adult patients with more than 20 yrs.
• American Society of Anesthesiologists Class I or II.

Exclusion criteria

• Those with unstable hemodynamics
• Those who can not undergo Bispectral index monitoring
• Those with previous history of stroke

Trial design

100 participants in 2 patient groups

Gynecologic surgery group

Description:

Those undergoing gynecologic laparoscopic surgery with TIVA

Urologic surgery group

Description:

Those undergoing urologic surgery with TIVA