Predicting Chemo Toxicity Using Geriatric Forms

Çanakkale Onsekiz Mart University

Status: Active, not recruiting

Conditions: Oncology; Geriatric Oncology; Physiology

Study type: Observational

Funder types: Other

Identifiers

NCT07163169

COMU-FNO-1

Details and patient eligibility

About

This prospective observational study aims to evaluate and compare the effectiveness of three geriatric assessment tools-CARG (Cancer and Aging Research Group score), G8 screening tool, and Frailty Scale-in predicting chemotherapy-related toxicity (CRT) in cancer patients aged 65 years and older. A total of at least 100 patients receiving standard chemotherapy (excluding hematologic malignancies and immunotherapy) at Çanakkale University Medical Faculty Oncology Clinic will be assessed prior to treatment initiation. Each participant will undergo baseline evaluations including G8, CARG, and Frailty assessments. The study will analyze the correlation between these tools and the occurrence of CRT using AUC, logistic regression, and correlation analyses. The goal is to identify the most accurate and practical screening tool to guide clinical decision-making and minimize chemotherapy toxicity in older adults.

Enrollment: 150 estimated patients

Sex: All

Ages: 65+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients aged 65 years or older.
• Histologically confirmed cancer diagnosis with a pre-planned chemotherapy regimen (adjuvant, neoadjuvant, or palliative intent).
• Chemotherapy not yet initiated at the time of enrollment.
• Clinically stable condition, as assessed by the oncologist.
• Willingness and ability to provide written informed consent.

Exclusion criteria

• Presence of acute infection or advanced organ failure (cardiac, hepatic, or renal).
• Severe psychiatric illness or cognitive impairment that interferes with the ability to complete assessments.
• Patients receiving concurrent hormonal therapy, targeted therapy, immunotherapy, or radiotherapy.
• Diagnosis of hematologic malignancies (e.g., leukemia, lymphoma, myeloma).