Predicting Complications of Hepatolithiasis After Hepatectomy

Wenzhou Medical University

Status: Invitation-only

Conditions: Complication; Liver Diseases

Treatments: Diagnostic Test: radiological evaluation

Study type: Observational

Funder types: Other

Identifiers

NCT05556434

prognosis of hepatolithiasis

Details and patient eligibility

About

Postoperative complications seriously affect the recovery of patients undergoing hepatectomy. Identifying risk factors and develop predictive models of complications for patients with hepatolithiasis undergoing hepatectomy is important for clinical practice.

Full description

Along with the change of lifestyle and dietary habits, many people are diagnosed with hepatolithiasis that is especially prevalent in Asia. Liver resection remains the favorable curative therapy for hepatolithiasis with a relatively low recurrence rate. Although there have been great improvements in surgical techniques and perioperative management, postoperative complications remain commonplace and seriously threat the recovery of patients undergoing hepatectomy. Therefore, it is important to identify risk factors of complications to improve the overall prognosis of patients. We want to collect the clinical information of patients with hepatolithiasis undergoing hepatectomy, including demographic data , laboratory index, histological features and postoperative complications. Patients are followed up at a interval of 3 month after treatment, and the survival data and recurrence rate are recorded. Then the relationship between clinical data and short-term outcomes after surgery are explored. Then models based on clinical features are developed to predict short-term outcomes after hepatectomy.

Enrollment: 500 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• pathologically diagnosed hepatolithiasis
• without malignancies
• receiving liver resection
• Eastern Cooperative Oncology Group performance status (ECOG-PS) 0-2
• Child-Pugh score of ≤7
• complete clinical and follow-up information
• age between 18-80 years old

Exclusion criteria

• with malignancies
• receiving other treatments
• Eastern Cooperative Oncology Group performance status (ECOG-PS) >2
• Child-Pugh score of >7
• incomplete clinical data
• lost to follow up
• age <18 years old or >80 years old

Trial design

500 participants in 2 patient groups

patients with postoperative complications

Description:

Patients who experienced postoperative complications were divided into the first group. The complications were defined according to the Clavien-Dindo classification system.

Treatment:

Diagnostic Test: radiological evaluation

patients without postoperative complications

Description:

Patients who didn't experience postoperative complications were divided into the second group.

Treatment:

Diagnostic Test: radiological evaluation