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This observational study seeks to identify and validate novel soluble biomarkers (within blood, synovial fluid, urine) which contribute to the prognostic assessment of an individual with an acute knee injury, a group of individuals in which ~50% will progress to symptomatic radiographic knee osteoarthritis (OA).
150 individuals will be followed over 5 years with clinical assessment including validated questionnaires, biological sampling and radiological imaging (X ray, magnetic resonance imaging (MRI)).
Enrollment
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Exclusion criteria
Knee injured more than 8 weeks prior to recruitment
Pre-existing advanced radiographic OA (Kellgren Lawrence (KL) grade 3-4) of same side knee at baseline
Known history of inflammatory/septic arthritis of same side knee
Knee replacement - previous or planned within 2 years of study start
Active other (treated) inflammatory disease or infection
Positive pregnancy test
Not consenting, or contraindication to provide blood samples:
Unable to give informed written consent in English
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Data sourced from clinicaltrials.gov
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