Predicting Risk for Post-polypectomy Colorectal Cancer (PREDICT)

Kaiser Permanente

Status: Withdrawn

Conditions: Colorectal Adenoma; Colorectal Polyp; Neoplasm, Colorectal; Colorectal Cancer

Treatments: Device: Logistic regression risk model

Study type: Interventional

Funder types: Other

Identifiers

NCT05606081

1547728-4

Details and patient eligibility

About

This originated as an observational study of Kaiser Permanente Northern California (KPNC) patients with a history of adenoma diagnosed by colonoscopy who received a subsequent surveillance colonoscopy between 2014 and 2019. The original goal of the study was to develop a risk prediction model that would help identify patients at highest risk for a diagnosis of advanced neoplasia (colorectal cancer and/or advanced adenoma) at or within 6 months following their surveillance colonoscopy. Candidate predictors of interest included patient demographics, medical history, and details related to the index colonoscopy. The investigators are now at the implementation stage and applying the risk prediction model to patients awaiting surveillance colonoscopy at select KPNC service areas to help identify those at highest risk for colorectal cancer based on their risk scores.

Full description

In the implementation stage, the risk prediction model is being applied to patients who are awaiting surveillance colonoscopy at select KPNC service areas to help identify those at highest risk for colorectal cancer based on their risk scores. The prediction model is being used in 2-3 service area to identify about 60-80 patients per month who are at highest risk for colorectal cancer based on their risk scores. Risk scores represent one of a number of factors being considered for prioritizing patients for colonoscopy.

Sex: All

Ages: 18 to 85 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

Patients are on the current colonoscopy pending list; excluding those who were fecal immunochemical test-positive, screening colonoscopies, had a colonoscopy in last 12 months or on a voluntary "pause" list

• Hereditary colorectal cancer syndrome (e.g. Lynch syndrome)
• Diagnostic, fecal immunochemical test -positive, or screening indication for colonoscopy

Trial design

Primary purpose: Health Services Research

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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0 participants in 1 patient group

Use of risk prediction scores

Experimental group

Description:

The prediction model is being used to identify patients who are at highest risk for colorectal cancer based on their risk scores.

Treatment:

Device: Logistic regression risk model