Predicting Severe Outcomes Among Children Hospitalized With Community-acquired Pneumonia

Fudan University

Status: Completed

Conditions: Child; Pneumonia; Prognosis

Treatments: Other: exposures of interest: epidemiological data, clinical characteristics, laboratory data, and chest radiographic reports

Study type: Observational

Funder types: Other

Identifiers

NCT05744609

20230203

Details and patient eligibility

About

In this study, investigators aimed to develop and validate a risk score to predict severe outcomes (e.g., mortality and ICU admission) in children who were admitted to the Children's Hospital of Fudan University between 2017 and 2022 due to community-acquired pneumonia (CAP). The objectives were as follows.

1. Develop a risk prediction model based on demographic, comorbidity, clinical characteristics, laboratory data, and chest radiographic reports to predict severe outcomes among children hospitalized with CAP;
2. Develop a risk scoring system and determine the cut-off point;
3. Externally validate the easy-to-use risk score.

Enrollment: 6,000 patients

Sex: All

Ages: 29 days to 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Aged between 29 days and 18 years old;
2. Admitted to hospital with signs or symptoms of acute infection (eg, fever) and acute respiratory illness (eg, cough), and radiographic evidence of pneumonia.

Exclusion criteria

1. Pneumonia developed 48 hours after admission or intubation;
2. Chronic pneumonia, tuberculosis, tracheobronchial foreign bodies, aspiration pneumonia, parasitic lung disease, and diffuse pulmonary interstitial/parenchyma disease.

Trial design

6,000 participants in 1 patient group

children hospitalized with community-acquired pneumonia

Treatment:

Other: exposures of interest: epidemiological data, clinical characteristics, laboratory data, and chest radiographic reports