Predicting Success of HFNC: The Utility of the ROX Index

Vall d'Hebron University Hospital (HUVH)

Status: Completed

Conditions: Pneumonia; Acute Respiratory Failure

Treatments: Procedure: mechanical ventilation

Study type: Observational

Funder types: Other

Identifiers

NCT02834325

PR(AG)101/2011

Details and patient eligibility

About

The purpose of the study was to describe early predictors and to develop a prediction tool that accurately identifies the need for mechanical ventilation in pneumonia patients with acute respiratory failure treated with High Flow nasal cannula.

Full description

Purpose The purpose of the study is to describe early predictors and to develop a prediction tool that accurately identifies the need for mechanical ventilation (MV) in pneumonia patients with hypoxemic acute respiratory failure (ARF) treated with high-flow nasal cannula (HFNC).

Materials and methods This is a 4-year prospective observational 2-center cohort study including patients with severe pneumonia treated with HFNC. High-flow nasal cannula failure was defined as need for MV. ROX index was defined as the ratio of pulse oximetry/fraction of inspired oxygen to respiratory rate.

Enrollment: 201 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• diagnosis of acute respiratory failure secondary to pneumonia receiving HFNC therapy

Exclusion criteria

• younger than 18 years old
• indication for mechanical ventilation at ICU admission
• limitation of therapeutic effort

Trial design

201 participants in 2 patient groups

exit

Description:

HFNC with no need for mechanical ventilation

failure

Description:

HFNC with need for mechanical ventilation

Treatment:

Procedure: mechanical ventilation