Predicting Survival After Surgical Resection for the Entire Spectrum of Anatomically Resectable HCC

National Cancer Centre, Singapore

Status: Completed

Conditions: Hepatocellular Carcinoma Resectable

Study type: Observational

Funder types: Other

Identifiers

NCT06294808

2017-2601

Details and patient eligibility

About

Clinical outcomes after surgical resection in HCC is a continuum and is clearly related to tumor burden but needs better definition. The researchers describe the use of the "metro ticket" approach to analyze surgical outcomes over the whole spectrum of anatomically resectable HCC to define overall survival including intermediate stage tumors (BCLC B). The analysis the researchers provide in this study enables the clinician to select the optimal surgical resection candidate based on robust long term survival data.

In addition, study compares outcome for open surgery vs laparoscopic surgery, survival outcome for viral and non-viral HCC using Albumin-Bilirubin (ALBI) for more comprehensive study result.

Full description

Patients who underwent surgical resection (both open surgery and laparoscopic surgery) for HCC from 1st January 2000 to 30th June 2018 by the joint hepato-pancreato-biliary surgery service at the Singapore Healthcare Group of Hospitals (Singapore General Hospital and the National Cancer Centre Singapore) were retrospectively identified from a prospectively kept institutional database.

The assessment of the size, number of nodules and vascular invasion of HCC were based on pre-operative CT/MRI imaging and pathological assessment of the resected specimens. All resections were histologically confirmed as HCC. Patients with macrovascular invasion and extrahepatic invasion were excluded from analysis as were patients resected for other palliative intents (e.g. ruptured HCC).

Enrollment: 1,043 patients

Sex: All

Ages: 21 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Unequivocal diagnosis of Hepatocellular Carcinoma (HCC) by histology
2. Patients who underwent surgical resection for HCC

Exclusion criteria

1. Patients who underwent liver resection for other malignancies ie cholangiocarcinoma
2. Patients with HCC who did not undergo liver resection.
3. Patients with HCC who underwent liver transplant.