Predicting the Metabolic Biomarkers Associated With Injury in Athletes

Shanghai Jiao Tong University

Status: Not yet enrolling

Conditions: Sports Medicine

Study type: Observational

Funder types: Other

Identifiers

NCT06888635

XH-25-003

Details and patient eligibility

About

For elite athletes, sports injuries significantly impede the further enhancement of their competitive performance. Consequently, the significance of preventing, detecting, and addressing potential injury issues has become increasingly critical. Currently, the comprehensive evaluation of athletes' physical function and condition primarily depends on a range of physiological, biochemical, and immunological indicators. However, these methods have progressively exposed their limitations. As an advanced bioinformatics technology, omics research demonstrates unique advantages. By leveraging multi-omics research and analysis, it is possible to more accurately observe the physiological and biochemical changes that athletes undergo during training and competition, as well as their regulatory mechanisms. This approach can provide practical data, identify biomarkers that can warn of potential injuries, and offer precise guidance for training monitoring and injury prevention. It also provides a foundation for developing diverse, precise, and personalized sports programs and rehabilitation plans.

Full description

Investigators will collect fasting venous blood. White blood cell count, red blood cell count, erythrocyte specific volume, hemoglobin, C-reactive protein, procalcitonin, erythrocyte sediment rate, lactic acid,creatine kinase, liver function indicators, blood urea, blood creatinine, blood uric acid, blood testosterone, blood cortisol, immunoglobulin (IgG, IgA, IgM) and ferritin levels were measured. The levels of IL-2, IL-6, IL-1β and TNF-α were determined by ELISA. Blood samples were purified and analyzed by proteomics, metabolomics and lipidomics methods. Urine and stool samples were collected and analyzed by multi-omics method.

Enrollment: 60 estimated patients

Sex: All

Ages: 12 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Age： Athletes 12-30 years old
2. Acute injury during exercise: such as muscle, sprain, contusion, torn ligament, dislocation, fracture.

Exclusion criteria

1. Athletes with serious cardio-cerebrovascular disease and abnormal liver and kidney function
2. Recent use of drugs or supplements that affect metabolism.
3. Pregnancy, lactation or special conditions that may affect metabolism.

Trial design

60 participants in 3 patient groups

Acute Injury athletes

Description:

Athletes in sports, due to sudden external force or improper operation, resulting in body tissue damage in a short period of time. This injury usually has sudden and distinct traumatic features, and common types include: 1. Sprain: Joint due to excessive torsion or stretching, resulting in ligament damage. 2. Strain: An injury to a muscle or tendon caused by excessive stretching or contraction. 3. Contusion: A direct impact on the body part causes damage to the subcutaneous tissue, which may be accompanied by bruising. 4. Fracture: The bone is broken due to external force. 5. Dislocation: The joint is removed from its normal position due to external forces.

Healthy athletes

Description:

athletes with no acute injury in the last 3 months

Healthy

Description:

Healthy non-athlete population