Prediction and Management of Acute Kidney Injury With Explainable Artificial Intelligence (PRIME)

Seoul National University

Status

Not yet enrolling

Conditions

Acute Kidney Injury

Treatments

Other: PRIME solution

Study type

Interventional

Funder types

Other

Identifiers

NCT05937451

PRIME

Details and patient eligibility

About

The goal of this clinical trial is to compare the occurrence of acute kidney injury (AKI) in inpatients when information from the 'PRIME solution' (AKI prediction program utilizing artificial intelligence) is provided. The main questions it aims to answer are: •[When Artificial intelligence (AI) provides information regarding AKI occurrence prediction within 48 hours, what would change in the physician's behavior?] •[If provided with AI information, what would be the incidence of AKI, severe AKI (stage 2 or 3), kidney replacement therapy, and changes in mortality during hospitalization?] In the case of the intervention group that receives AI information, autonomous treatment is conducted by referring to AI prediction information. Researchers will compare it with a usual-care group that does not receive AI prediction results.

Full description

The investigators designed a prospective, investigator-initiated, single-center, single-blinded, randomized controlled study with two experimental groups. A total of 1438 participants with hospitalized patients will be enrolled and randomized into two groups; intervention or usual-care groups. The investigators will apply an AKI prediction model based on the patient's demographic. The investigators will collect data on vital signs, laboratory test results, medication history, and surgical records. The investigators provide information on whether AKI develops within 48 hours and the top 10 explanatory factors for predicting AKI to the physician. The intervention group receives the prediction results daily until the patient is discharged or up to 7 days after admission. The usual-care group does not receive analysis results.

Enrollment

1,438 estimated patients

Sex

All

Ages

19+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Inpatients aged > 18 years
Admitted to the Department of Nephrology, Geriatrics, Urology, Surgery, and Orthopedics
written consent

Exclusion criteria

Patients with a scheduled hospital stay of 2 days or less
Patients who have been hospitalized for more than 8 days since the date of hospitalization
Patients scheduled to be discharged the next day
Patients with last measured serum creatinine greater than 4.0 mg/dL or less than Estimated Glomerular Filtration Fate Chronic Kidney Disease Epidemiology Collaboration (eGFR-CKD-EPI) 15 ml/min/1.73 m2
Patients undergoing dialysis (Hemodialysis, peritoneal dialysis) due to end-stage renal disease
Declined to participate