Prediction of Acute Kidney Injury After Operation of Acute Type A Aortic Dissection Based on Multimodal Model

Shandong University

Status: Unknown

Conditions: Acute Kidney Injury; Aneurysm, Dissecting

Treatments: Diagnostic Test: Low CT Renal Perfusion imaging indexes; Diagnostic Test: Normal CT Renal Perfusion imaging indexes

Study type: Observational

Funder types: Other

Identifiers

NCT05017896

2020SDUCRCC031

Details and patient eligibility

About

Acute kidney injury is one of the most common postoperative complications of acute type A aortic dissection, which is closely related to early postoperative death. Early prevention, early diagnosis and early treatment are the key to improve the prognosis of such patients. It has been a hot topic in clinical research for a long time. Previous reports revealed a series of risk factors for acute kidney injury after aortic dissection, but limited by research design and single modal data, high quality studies were rare. The purpose of this study is to further clarify the risk factors by studying the relationship between preoperative CT renal perfusion imaging indexes and postoperative acute kidney injury; establish and externally verify the multimodal radiomics prediction model for acute kidney injury after operation of aortic dissection combining with preoperative CT renal perfusion imaging and CT angiography information by analysis methods of information fusion, feature engineering and radiomics, so as to guide the follow-up clinical practice, improve the prognosis of such patients and save medical resources.

Enrollment: 242 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. 18-70 years old
2. Acute type A aortic dissection diagnosed by CT angiography
3. Sign informed consent

Exclusion criteria

1. History of chronic kidney disease
2. History of cardiovascular operation
3. Acute kidney injury has occurred before operation
4. Pregnancy status

Trial design

242 participants in 2 patient groups

Normal Perfusion

Treatment:

Diagnostic Test: Normal CT Renal Perfusion imaging indexes

Low Perfusion

Treatment:

Diagnostic Test: Low CT Renal Perfusion imaging indexes