Prediction of Chronic Kidney Disease Following Pre-eclampsia: Diagnosis and Early Care (PRECEDE)

Centre Hospitalier le Mans

Status: Enrolling

Conditions: Preeclampsia

Treatments: Other: annual follow-up during 10 years

Study type: Interventional

Funder types: Other

Identifiers

NCT05056701

CHM-2020/S8/10

Details and patient eligibility

About

Pre-eclampsia (PE) is a pregnancy-associated syndrome of variable severity, classically defined by the combination of hypertension and proteinuria in a previously non-hypertensive or proteinuric patient. These symptoms normally resolve within 2-3 months after delivery regardless of the severity of the pre-eclampsia.

Regardless of its definition, preeclampsia is associated with an increased risk of obstetric events and, for the mother, an increased risk of developing chronic kidney disease (CKD), hypertension, diabetes and cardiovascular disease in the broad sense.

The relationship between preeclampsia and Chronic Kidney Disease is, however, complex and not fully understood.

Investigator proposes an interventional study to identify the diagnosis of Chronic Kidney Disease in patients who have developed an episode of Preeclampsia.

Enrollment: 400 estimated patients

Sex: Female

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Meeting the preeclampsia criteria or one of its complications (eclampsia, HELLP syndrome) according to the ISSHP 2018 definitions within the last 5 years
• Having signed the informed consent
• Person affiliated to social security

Exclusion criteria

• Patient with mental disability or language barrier preventing understanding of the study or consent
• Person deprived of liberty by judicial or administrative decision
• Person under forced psychiatric care
• Person subject to a legal protection measure

Trial design

Primary purpose: Prevention

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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400 participants in 1 patient group

patient with preeclampsia

Experimental group

Description:

Patient meeting preeclampsia criteria according to International Society for the Study of Hypertension in Pregnancy (ISSHP) 2018 definitions

Treatment:

Other: annual follow-up during 10 years