PREdiction of DIagnosed Covid-19 infecTion in IUC Patients (PREDICT)

University Hospital, Lille

Status: Completed

Conditions: Infection Viral; Pneumonia; ARDS; Coronavirus

Study type: Observational

Funder types: Other

Identifiers

NCT04327180

2020-A00763-36 (Other Identifier)

2020_20

Details and patient eligibility

About

Coronavirus 2019 (COVID-19) is a respiratory tropism virus transmitted through droplets emitted into the environment of infected persons. The symptoms can be extremely varied and the course can range from spontaneous healing without sequelae to death.

Currently, the diagnosis of certainty for resuscitation patients (by definition "severe") is based on searching for a fragment of virus genetic material within the epithelial cells of the respiratory tree, up and/or down, by PCR.

It is to be expected that the epidemic peak will make it difficult (if not impossible) to respect the stereotypical path that is currently in place, due to the lack of space in the specific unit. This will require optimization of care pathways and use of the specific sectors.

It is therefore necessary to define the simple criteria, available from the moment patients are admitted, to predict the result of the COVID-19 PCR.

Enrollment: 368 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All patient admitted in ICU Lille Hospital and hospitalized in the unit "Emergent Biological Risk" (REB) before a suspicion of infection with COVID-19
• Clinical infectious syndrome: fever (>38°C) or hypothermia ( 36°C), chill, fever at home
• a severe respiratory table defined by:
• Oxygen demand > 3 L/min in the presence of significant comorbidity (pregnancy, chronic respiratory disease, chronic heart disease, hemopathy, cirrhosis) or > 6 L/min in the absence of comorbidity
• or a respiratory rate > 30 cycles per minute
• the need for mechanical, invasive or non-invasive ventilation
• the need for humidified high-flow oxygen therapy

Exclusion criteria

• Patient already included in study for first stay
• Cirrhosis CHILD C
• Major surgery in the last 7 days Minor patient
• Patient under guardianship or curatorship
• Refusal to participate
• No social security coverage.

Trial design

368 participants in 1 patient group

patients suspected of infection with COVID-19.

Description:

Patients included with positive PCR and patients with negative PCR included