Prediction of Early Recovery of Liver Function After LDLT in Children: An Ambispective Cohort Study

Huiwu Xing

Status: Completed

Conditions: Other End-stage Liver Diseases in Children; Liver and Biliary Tract Disorders in Duration of Pregnancy

Study type: Observational

Funder types: Other

Identifiers

NCT06045949

DRHFafterLDLT

Details and patient eligibility

About

The investigators included children with living donor liver transplantation (LDLT) from January 1, 2018 to July 31, 2022 as a retrospective cohort, and the group from August 1, 2022 to June 30, 2023 as a prospective cohort. The investigators collected the demographic and clinicopathological data of donors and recipients, and determined the risk factors of early postoperative delayed recovery of hepatic function (DRHF) by univariate and multivariate Logical regression analyses.

Enrollment: 230 patients

Sex: All

Ages: Under 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. children with the indication of LDLT [cholestatic liver disease (such as BA), metabolic liver disease (such as Wilson's disease and Ornithine transcarbamylase deficiency), acute liver failure (such as drug induced), neoplastic disease (such as hepatoblastoma), vascular disease (such as cavernous transformation of portal vein and congenital absence of portal vein), re-transplantation and others];
2. the relatives of the children voluntarily donated part of the liver which met the requirements of LDLT.

Exclusion criteria

1. recipients with contraindications of LDLT (such as coagulation dysfunction, acute infection, cardiopulmonary failure);
2. failure to complete LDLT due to various reasons (such as death during or within 3 days after operation);
3. recipients or donors with incomplete necessary data.

Trial design

230 participants in 1 patient group

living donor liver transplantation in children