Prediction of Extubation Failure: A Multicenter Prospective Observational Study

Chongqing Medical University

Status: Enrolling

Conditions: Mechanical Ventilation

Study type: Observational

Funder types: Other

Identifiers

NCT05069441

ChongqingMU4

Details and patient eligibility

About

The investigators intend to collect several variables to predict extubation failure among patients who successfully complete a spontaneous breathing trial, and then develop a scale using simple bedside indicators to predict extubation failure.

Full description

Mechanically ventilated patients who successfully completed a spontaneous breathing trial and prepared for extubation are eligible to enroll in this study. The vital signs, arterial blood gas tests, cough strength, cuff leak test, use of noninvasive ventilation et al. are collected. Patients are followed up to postextubation 28-day or discharge. Extubation failure is defined as reintubatin or death within postextubation 7 days. First, we will analyze the data to predict extubation failure. Then, we will combine several easily obtained variables to develop and validate a scale to predict extubation failure. Finally, we explore the predictive power of extubation failure tested by the scale and find the cutoff value to distinguish the low, moderate and high risk of extubation failure.

Enrollment: 2,604 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Prepared for extubation through spontaneous breathing trial;Oral or nasal endotracheal intubation; be at least 18 years old

Exclusion criteria

• Extubation without a spontaneous breathing trial ;Reintubation due to secondary surgery; Tracheotomy

Trial design

2,604 participants in 1 patient group

Patients with extubation after a weaning trial

Description:

Patients who sucessfully complete a spontaneous breathing trial are enrolled in this group.