Prediction of Incidence of Liver Cancer by Use of Real-time Tissue Elastography (PICTURE)

Kindai University

Status: Unknown

Conditions: Chronic Hepatitis B; Chronic Hepatitis C

Study type: Observational

Funder types: Other

Identifiers

NCT01360892

JLOG1003

Details and patient eligibility

About

This is a multi-center cohort study in which the Real-time Tissue Elastography® measurements will predict prospectively the incidence of hepatocellular carcinoma, the incidence and severity of gastroesophageal varices ascites and decompensated cirrhosis in hepatitis B or C patients.

Full description

The aim of this study is to validate the predictive value of Real-time Tissue Elastography® by comparison with serum marker or FibroScan® in chronic hepatitis B or C patients.

Every year and for three years, we performed Real-time Tissue Elastography®, blood sampling, gastrointestinal endoscopy. If in the hospital they can perform FibroScan®, FobroScan® also be performed.

Subjects were also performed ultrasonography (US), computed sonography (CT) or magnetic resonance imaging (MRI) evry four or six months.

The time between the Real-time Tissue Elastography®, blood sampling, gastrointestinal endoscopy and FiroScan® must not exceed four weeks.

Enrollment: 1,000 estimated patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Male or female and at least 20 years of age
• Chronic hepatitis B or Chronic hepatitis C

Exclusion criteria

• Evidence or history of hepatocellular carcinoma
• History of alcohol abuse (alcohol intake > 20g/day)
• Pregnant or lactating patients
• Psychosis