Prediction of Long-term Outcome in Aortic Stenosis After Valve Intervention

Uppsala University

Status: Enrolling

Conditions: Aortic Stenosis

Treatments: Other: There is no intervention since it is an observational study patients are treated according to clinical praxis

Study type: Observational

Funder types: Other

Identifiers

NCT05629104

Bio-AS

Details and patient eligibility

About

Patients with severe aortic stenosis accepted for transcatheter intervention or open surgery are included before the intervention, and then followed up with clinical visits during the first year after intervention. Imaging with echocardiography and computed tomography (CT) are performed together with additional imaging with magnetic resonance imaging (MRI) and Positron emissions tomography (PET)-CT in a subgroup of the study population. Blood samples, physical performance and questionnaires with focus on frailty and heart failure are also collected at each visit. A follow up with information of the outcomes after 2-5 years will be performed through national registries.

Enrollment: 300 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Accepted for aortic valve intervention

Exclusion criteria

• No able to follow the study protocol

Trial design

300 participants in 2 patient groups

Preserved heart function

Description:

The group will be defined as preserved left ventricular ejection fraction (LVEF) with and without hypertrophy and with and without reduced global longitudinal strain (GLS).

Treatment:

Other: There is no intervention since it is an observational study patients are treated according to clinical praxis

Reduced heart function

Description:

The group will be defined as reduced LVEF

Treatment:

Other: There is no intervention since it is an observational study patients are treated according to clinical praxis