Prediction of Lymph Node Invasion for Prostate Adenocarcinoma (PRED-NCHIR)

Regional University Hospital Center (CHRU)

Status: Unknown

Conditions: Adenocarcinoma of the Prostate

Study type: Observational

Funder types: Other

Identifiers

NCT04909957

29BRC20.0290

Details and patient eligibility

About

Despite lymph node involvement (LNI) being one of the main prognostic factors in patients with prostate cancer (PCa), pelvic lymph node irradiation remains debated, possibly due to an insufficient selection of patients. Significant advances in LNI risk modelling have been achieved with the addition of visual interpretation of magnetic resonance imaging (MRI) data, but it is likely that quantitative analysis could further improve prediction models. In this study, the investigators aimed to develop and internally validate a novel LNI risk prediction model based on radiomic features extracted from pre-operative multimodal MRI.

Enrollment: 400 estimated patients

Sex: Male

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Histologically proven adenocarcinoma of the prostate treated by prostatectomy with extensive lymph node dissection
• Available pre-operative +/- PET choline

Exclusion criteria

• Unanalyzable pre-operative MRI

Trial design

400 participants in 2 patient groups

Absence of invaded lymph node after extensive lymph node dissection

Description:

Absence of invaded lymph node after extensive lymph node dissection

Presence of invaded lymph node after extensive lymph node dissection

Description:

Presence of invaded lymph node after extensive lymph node dissection