Prediction of Non-motor Symptoms in Fully Ambulatory MS Patients Using Vocal Biomarkers (COMMITMENT)

Insel Gruppe AG, University Hospital Bern

Status: Completed

Conditions: Multiple Sclerosis

Treatments: Other: Voice analysis

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT05561621

DLF5177

Details and patient eligibility

About

The investigator will set up a study evaluating vocal biomarkers in people with MS in order to identify persons with non-motor symptoms: depression, cognitive deterioration, and fatigue. Up to now, to the best of the investigator's knowledge, there is no study reporting the use of vocal biomarkers to predict these three non-motor symptoms in people with MS.

Enrollment: 70 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Relapsing MS
• Age over 18
• EDSS < 4.0
• Capability of written informed consent

Exclusion criteria

• Not fluent in german language
• Relapse or Steroids per os/intra venous < 4 weeks prior to examination
• KM enhancing lesion in MRI < 4 weeks prior to examination
• Other previous disease affecting the speech
• Pregnant patients
• Mental disability and not able to understand the protocol and study tasks in german languagePatients with greater physical and cognitive disability or history of major depressive disorder and suicide attempt/suicidal thoughts
• Patients with sleep disorders and comorbidities associated with extreme fatigue (e.g., fibromyalgia)

Trial design

70 participants in 2 patient groups

Patients with relapsing MS

Treatment:

Other: Voice analysis

Healthy controls

Treatment:

Other: Voice analysis