Prediction of Outcome in Severe Preeclampsia

Cairo University (CU)

Status: Completed

Conditions: Leiden Factor V Deficiency,Preeclampsia; Palental Pathology; Doppler Examination

Treatments: Diagnostic Test: blood sample , doppler of uterine vessel and placenta

Study type: Observational

Funder types: Other

Identifiers

NCT03871764

019002

Details and patient eligibility

About

this summary studied the predictive values of factor V Leiden mutation , doppler indices , placental pathology to unfavorable fetal and maternal outcomes

Full description

leiden mutation is activated protein C resistance with hypercoagulable states and increased thrombotic risk. 99 % are heterozygous and 1 % is homozygous , very rare cases are psoudohomozygous with factor V deficiency. relation to this mutation was studied in severe preeclamptic patients. doppler indices of uterine arteries , increased pulsetility index or unilateral or bilateral uterine artery notch and placental pathology were studied.

Enrollment: 100 patients

Sex: Female

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria: severe preeclampsia in 3rd trimester -

Exclusion Criteria:Twin pregnancy. Fetal congenital anomalies. Diabetic patient, impaired renal function. Any medical disorders even that HTN. Any placental pathology,Autoimmune diseases. Women with uterine activity or clinical emergencies with maternal hemodynamic instability or an indication for immediate termination of pregnancy.