Prediction of Risk of Vascular Structural Damage in Patients with Large Vessel Vasculitis (LVV) Based on PET/MRA Image Evaluation System

Nanjing Medical University

Status: Enrolling

Conditions: Large Vessel Vasculitis

Treatments: Drug: glucocorticoid, immunosuppressants, targeted therapy

Study type: Observational

Funder types: Other

Identifiers

NCT06824714

2024-SR-693

Details and patient eligibility

About

Large vessel vasculitis (LVV) causes vascular inflammation, leading to serious complications such as aneurysm formation and stroke. It is difficult to identify the inflammation of the vessel wall by the current imaging methods, thus affecting the timing of treatment and selection of treatment options. Improved examination methods to determine disease activity are highly needed to guide treatment.

Full description

This study was designed to assess vascular wall inflammation in patients with large vessel vasculitis by positron emission tomography and magnetic resonance imaging (PET/MRA). The study has a 12-month follow-up period. After completing the baseline clinical assessment, laboratory test and PET/MRA assessment, the intervention protocol will be determined by clinicians. The patients will visit the clinic every 1-2 months according to their specific conditions. Clinical assessment, laboratory test and PET/MRA re-examination will be completed at 6 and 12 months after treatment.

Enrollment: 150 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Clinically suspected or confirmed LVV and willing to undergo PET/MRA
2. Compliance with long-term follow-up
3. Sign informed consent.

Exclusion criteria

1. Patients with other serious cardiovascular and cerebrovascular diseases, malignant tumors, infectious diseases, severe renal insufficiency.
2. Severe mental disorders, severe claustrophobia unable to cooperate with the examination.
3. Patients equipped with cardiac pacemaker, artificial heart valve, ferromagnetic vascular clamp after vascular surgery, aneurysm clamp, artificial cochlea, insulin pump and other drug dosage control devices, steel nail plate and other metal internal fixation, artificial joint, electronic eye, artificial eye.
4. Allergic to contrast medium.
5. Pregnant or lactating women.

Withdrawal criteria:

1. Any exclusion criteria emerged during patient follow-up.
2. Voluntarily withdrew from the study.

Trial design

150 participants in 1 patient group

Clinically suspected or confirmed large vessel vasculitis (LVV)

Treatment:

Drug: glucocorticoid, immunosuppressants, targeted therapy