PREdiction of succeSSful weanING From Continuous Renal Replacement Theraphy: the Possible Role of Delta C-cistatin (PRESSING)

Scientific Institute for Research Hospitalization and Healthcare (IRCCS)

Status: Enrolling

Conditions: Acute Kidney Injury

Study type: Observational

Funder types: Other

Identifiers

NCT06714214

PRESSING

Details and patient eligibility

About

The goal of this observational study is to know if, in patients with acute kidney injury, naive for renal injurie, admitted to different ICUs, the change in plasma concentration of c-cistatin, between initiation and discontinuation of CRRT, is a predictive finding to optimize the withdrawal time of renal support

Enrollment: 152 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age ≥ 18 years;
• diagnosis of acute kidney injury (defined according to KDIGO 2012 criteria)
• need for support with CRRT according to the indications of the nephrologist consultants and Clinical Practice
• Obtaining informed consent

Exclusion criteria

• CRRT already ongoing (in another department not participating in the study) at the time of transfer/admission to intensive care;
• need for RRT (any type and modality) in the 14 days prior to enrolment;
• diagnosis of AKD/CKD/ESRF on admission;
• Discontinuation of CRRT under conditions that do not comply with the criteria established by the study;
• Need for CRRT not associated with AKI condition (e.g. elimination of toxicants);
• pregnant women;
• presence of known thyreopathy
• Continuous use of corticosteroids
• patient with known neoplastic disease.