Prediction Value of Ecg on Coronary Slow-flow (PECS)

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Sun Yat-sen University

Status

Completed

Conditions

Coronary Slow Flow

Treatments

Procedure: angiography

Study type

Observational

Funder types

Other

Identifiers

NCT02650557
PECS-sysu

Details and patient eligibility

About

The investigators aimed to investigate the vessel heterogeneity of Thrombolysis in Myocardial Infarction frame count (TFC) in the three coronary arteries, and its relation to P-wave dispersion, in patients with coronary slow flow and otherwise normal coronary arteries.

Full description

Coronary slow flow (CSF) phenomenon, which is characterized by delayed coronary opacification in the absence of obstructive epicardial coronary artery disease, is a relatively common finding in patients undergoing routine coronary angiography and is often associated with chest pain. In some patients with CSF, blood flow may be heterogeneously distributed in the three coronary arteries, suggesting the heterogeneously distributed microvascular dysfunction in the myocardium. However, the vessel heterogeneity of Thrombolysis in Myocardial Infarction (TIMI) frame count (TFC) has not been fully elucidated. P-wave dispersion (PWD) is defined as the difference between the longest and the shortest P-wave duration recorded from multiple different surface electrocardiogram (ECG) leads, and it has been reported to be associated with inhomogeneous and discontinuous propagation of sinus impulses5, which are well known electrophysiologic characteristics of the atrium prone to fibrillation. Although it is plausible to hypothesize that PWD might be associated with the heterogeneously distributed microvascular dysfunction, and previous studies have demonstrated the abnormal PWD in patients with CSF, the correlation between TFC heterogeneity and PWD has never been evaluated. In this study, the investigators aimed to investigate the vessel heterogeneity of TFC in the three coronary arteries, and its relation to PWD, in patients with CSF and otherwise normal coronary arteries.

Enrollment

998 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • All of the subjects had chest pain and were referred to our catheterization laboratory for coronary angiography

Exclusion criteria

  • Valvular or congenital heart disease
  • Atrial fibrillation or other arrhythmia that would interfere with ECG analysis
  • Left ventricular hypertrophy
  • Myocardial or pericardial disease
  • Chronic obstructive pulmonary disease, or electrolyte abnormalities.
  • Subjects taking antiarrhythmic, antiischemic, β-blocker, or calcium-channel blocker medications were also excluded from the study.

Trial design

998 participants in 2 patient groups

CSF group
Description:
consecutive patients with angiographically documented CSF
Treatment:
Procedure: angiography
control group
Description:
age- and gender-matched control subjects
Treatment:
Procedure: angiography

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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