Predictive Ability of PEEP Induced Changes in CVP to Predict Volume Responsiveness in Mechanically Ventilated Patients After Major Abdominal Surgery

University Hospital Dubrava

Status: Unknown

Conditions: Surgery; Critical Illness; Cardiac Output, Low

Treatments: Procedure: PEEP increase

Study type: Interventional

Funder types: Other

Identifiers

NCT04191408

20196996

Details and patient eligibility

About

Interventional study which will assess whether an positive end expiratory pressure induced increase of central venous pressure is a valid predictor of volume responsiveness in mechanically ventilated patients after major abdominal surgery assessed by increase of cardiac output after passive leg raise.

Full description

Interventional study which will assess whether an positive end expiratory pressure induced increase of central venous pressure is a valid predictor of volume responsiveness in mechanically ventilated patients after major abdominal surgery assessed by increase of cardiac output after passive leg raise.

Enrollment: 60 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Mechanically ventilated and sedated patients admitted to the ICU after major abdominal surgery

Exclusion criteria

• Heart failure NYHA III or more
• Severe obstructive or restrictive lung disease
• Hypotension with MAP < 60 mmHg
• Tachycardia > 140 beats / min

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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60 participants in 1 patient group

Mechanically ventilated patients after surgery

Experimental group

Description:

After ICU admission the patient's hemodynamics (MAP, HR, CO, PPV) will be measured in supine position. It will be remeasured after PEEP has been increased from +5 to +15 cmH20. Then the baseline measurement will be repeated. Then passive leg raise will be performed and all the parameters will be remeasured.

Treatment:

Procedure: PEEP increase