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Predictive Ability of PEEP Induced Changes in CVP to Predict Volume Responsiveness in Mechanically Ventilated Patients After Major Abdominal Surgery

U

University Hospital Dubrava

Status

Unknown

Conditions

Surgery
Critical Illness
Cardiac Output, Low

Treatments

Procedure: PEEP increase

Study type

Interventional

Funder types

Other

Identifiers

NCT04191408
20196996

Details and patient eligibility

About

Interventional study which will assess whether an positive end expiratory pressure induced increase of central venous pressure is a valid predictor of volume responsiveness in mechanically ventilated patients after major abdominal surgery assessed by increase of cardiac output after passive leg raise.

Full description

Interventional study which will assess whether an positive end expiratory pressure induced increase of central venous pressure is a valid predictor of volume responsiveness in mechanically ventilated patients after major abdominal surgery assessed by increase of cardiac output after passive leg raise.

Enrollment

60 estimated patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Mechanically ventilated and sedated patients admitted to the ICU after major abdominal surgery

Exclusion criteria

  • Heart failure NYHA III or more
  • Severe obstructive or restrictive lung disease
  • Hypotension with MAP < 60 mmHg
  • Tachycardia > 140 beats / min

Trial design

Primary purpose

Diagnostic

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

60 participants in 1 patient group

Mechanically ventilated patients after surgery
Experimental group
Description:
After ICU admission the patient's hemodynamics (MAP, HR, CO, PPV) will be measured in supine position. It will be remeasured after PEEP has been increased from +5 to +15 cmH20. Then the baseline measurement will be repeated. Then passive leg raise will be performed and all the parameters will be remeasured.
Treatment:
Procedure: PEEP increase

Trial contacts and locations

1

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Central trial contact

Andrej Šribar, MD, PhD

Data sourced from clinicaltrials.gov

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