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Predictive Factor Study of the Occurrence of Endometrial Cancer in Patients With Lynch Syndrome (PrediLynch)

U

University Hospital, Lille

Status

Completed

Conditions

Lynch Syndrome

Treatments

Other: questionnaire assesment

Study type

Observational

Funder types

Other

Identifiers

NCT04452266
2020-A00843-36 (Other Identifier)
2020_07

Details and patient eligibility

About

Lynch Syndrome increases Endometrial Cancer Occurrence in women due to failure in MisMatch Repair System. Lifetime Cumulative risk of developing endometrial Cancer is approximatively 40% in women with Lynch Syndrome.

Endometrial cancer is the third women cancer in France. Many risk factors are known in general population. Lots of factors are related to over exposure to estrogen.

Data about influence of general risk factors in Women with Lynch Syndrome are poor. Recently, a cohort study appears to have shown a significant decrease in the risk of endometrial cancer with multiparity, the use of hormonal contraception and late menopause in Lynch women. The impact of weight and certain metabolic parameters on the occurrence of endometrial cancers remains poorly known to this day.

Enrollment

150 patients

Sex

Female

Ages

30+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Lynch Syndrome Diagnosis at University Hospital
  • Alive at study time
  • Age over 30 at endometrial cancer or Lynch Syndrome Diagnosis

Case group :

  • No cancer before endometrial cancer diagnosis

Control group :

  • No endometrial cancer developped
  • Free cancer women at Lynch Syndrome diagnosis

Exclusion criteria

  • Refusing to participate
  • Poor understanding of the French language
  • Other cancer diagnosed before endometrial cancer
  • Hysterectomy before lynch diagnosis for free cancer women

Trial design

150 participants in 2 patient groups

case group
Description:
Women with Lynch Syndrome and endometrial Cancer matched on age of endometrial cancer diagnosis
Treatment:
Other: questionnaire assesment
control group
Description:
Women with Lynch Syndrome, without Cancer at Lynch Syndrome Diagnostic matched on their age at Lynch Diagnostic
Treatment:
Other: questionnaire assesment

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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