Predictive Factors for Survival in Aggressive Meningiomas (23Men)

Institute of Hospitalization and Scientific Care (IRCCS)

Status: Enrolling

Conditions: Anaplastic Meningioma; Meningioma Atypical; Meningioma

Treatments: Diagnostic Test: Biological biomarker assessment

Study type: Interventional

Funder types: Other

Identifiers

NCT05793034

3459

Details and patient eligibility

About

The investigators plan to collect clinical and molecular data, including ICH, PCR, NGS and methylome, from patients operated on for grade 2 or grade 3 meningioma. The purpose of the study is to identify reliable and easy-to-assess predictive factors for recurrence and survival after surgery.

Enrollment: 250 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

1. Patient operated for atypical (grade 2) meningioma; or
2. Patient operated for anaplastic (grade 3) meningioma;
3. Timeframe for surgery, 1999-2019

Exclusion criteria

1. Patient lost at follow-up

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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250 participants in 1 patient group

Biological biomarker assessment

Other group

Description:

FFPE tumor tissue will be processed with a number of molecular biology techniques

Treatment:

Diagnostic Test: Biological biomarker assessment