Predictive Factors of Disease-free Survival After Complete Pathological Response to Neoadjuvant Radiotherapy in Rectal Adenocarcinoma

Moroccan Society of Surgery

Status: Completed

Conditions: Rectal Neoplasms

Treatments: Procedure: rectal resection

Study type: Observational

Funder types: Other

Identifiers

NCT03601689

CompleteResponse

Details and patient eligibility

About

Many data suggest that patients with low rectal adenocarcinoma who achieved ypT0N0 status have improved survival and disease-free survival (DFS) compared to all other stages however only few data are available regarding the specific prognosis factors of this subgroup. This retrospective multicentric study aimed to predict the prognosis of patients with complete pathological response after neoadjuvant treatment.

Enrollment: 84 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria

• patients with a histologically proven low rectal adenocarcinoma,
• no previous or synchronous colorectal disease,
• UICC stage I-III patients who underwent neoadjuvant chemoradiotherapy or chemotherapy,
• followed by total mesorectal excision (TME), and
• a complete pathological response defined as ypT0N0

Exclusion Criteria:

• all patients with metastatic tumors or missing data