Predictive Factorsfor Final Pathologic Ureteral Sections (CYSTECTOMEN)

Centre Hospitalier Universitaire, Amiens

Status: Completed

Conditions: Urothelial Carcinoma

Treatments: Other: laparoscopic approach with an extended pelvic lymph

Study type: Observational

Funder types: Other

Identifiers

NCT03677544

PI2017_843_0051

Details and patient eligibility

About

To identify preoperative predictive factors for final ureteral section invasion after radical cystotomie (RC) and to validate significant factors on an external independent cohort. The investigators retrospectively reviewed data of all consecutive RC performed for bladder cancer in 2 high-volume institutions. Clinical, pathological, and follow-up data were collected prospectively and reviewed retrospectively. Pathological evaluation was performed by 2 well-trained uropathologists in each center. Logistic regression analyses were performed to identify predictive factors for final ureteral sections involvement. Significant factors in cohort A were validated in cohort B. Receiver operating curve and area under curve were modeled to evaluate predictive accuracy of the markers

Full description

To identify preoperative predictive factors for final ureteral section invasion after radical cystotomie (RC) and to validate significant factors on an external independent cohort. Pathological evaluation was performed by 2 well-trained uropathologists in each center (Y.A. and C.C). The investigators retrospectively reviewed data of all consecutive RC performed for bladder cancer in 2 high-volume institutions. Clinical, pathological, and follow-up data were collected prospectively and reviewed retrospectively. Pathological evaluation was performed by 2 well-trained uropathologists in each center. Logistic regression analyses were performed to identify predictive factors for final ureteral sections involvement. Significant factors in cohort A were validated in cohort B. Receiver operating curve and area under curve were modeled to evaluate predictive accuracy of the markers

Enrollment: 748 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients > 18 years
• patients reoperative predictive factors for final ureteral section invasion after radical cystectomy

Exclusion criteria

• patients < 18 years

Trial design

748 participants in 2 patient groups

no intraoperative FS examination

Description:

Surgery was performed through either open or laparoscopic approach with an extended pelvic lymph node dissection up to the common iliac bifurcation. procedures were performed between 1980 and 2013

Treatment:

Other: laparoscopic approach with an extended pelvic lymph

intraoperative FS examination

Description:

Surgery was performed through either open or laparoscopic approach with an extended pelvic lymph node dissection up to the common iliac bifurcation procedures were performed between 2001 and 2013

Treatment:

Other: laparoscopic approach with an extended pelvic lymph