Predictive Modeling of Necrotizing Skin Infections in Snakebite Patients

Guangzhou Institute of Respiratory Disease

Status: Completed

Conditions: Snakebite Envenomation; Necrotizing Skin Infections

Treatments: Procedure: Wound Debridement; Drug: Antivenom Serum

Study type: Observational

Funder types: Other

Identifiers

NCT06622343

KY20240521-001

Details and patient eligibility

About

This multicenter retrospective study aims to identify the risk factors associated with necrotizing skin infections following venomous snakebites and to develop a predictive model. Clinical data from 99 patients treated between January 2020 and April 2024 at three hospitals in Guangdong Province, China, were analyzed.

Full description

Venomous snakebites are a significant public health issue, particularly in tropical and subtropical regions like southern China. Necrotizing skin infections are a severe but relatively rare complication of venomous snakebites, often resulting from delayed treatment and bacterial invasion. This study retrospectively analyzed clinical data from 99 patients with venomous snakebites treated at three hospitals in Guangdong Province between January 2020 and April 2024. The primary objective was to identify the major risk factors associated with the development of necrotizing skin infections and to build a predictive model to assist in clinical decision-making.

The study included male and female patients aged 14 years and older. Patients with incomplete medical records, long-term use of immunosuppressants, or underlying immunodeficiency diseases were excluded. Multivariate logistic regression identified the Snakebite Severity Score (SSS), blood glucose levels, and D-dimer levels as significant independent predictors of necrotizing infections.

Enrollment: 99 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosis of venomous snake bites confirmed according to major international clinical guidelines and expert consensus.
• Availability of complete case data.
• Provision of written informed consent by the patients or their legal guardians.

Exclusion criteria

• Age less than 14 years.
• Long-term use of immunosuppressants or corticosteroids.
• Presence of concurrent immunodeficiency diseases (e.g., HIV positive).
• Severe malnutrition.
• Incomplete medical records.

Trial design

99 participants in 2 patient groups

Necrotizing Skin Infections Group

Description:

This cohort includes patients who developed necrotizing skin infections following venomous snakebites. These patients were treated at three hospitals in Guangdong Province between January 2020 and April 2024. The study aims to identify key risk factors, including Snakebite Severity Score (SSS), blood glucose levels, and D-dimer levels, that are associated with the development of necrotizing skin infections in these patients.

Treatment:

Drug: Antivenom Serum

Procedure: Wound Debridement

Non-Infection Group

Description:

This cohort includes patients who did not develop necrotizing skin infections after venomous snakebites. These patients were treated at the same three hospitals between January 2020 and April 2024. The cohort serves as a control group to compare against the infection group, helping to determine risk factors associated with necrotizing skin infections in snakebite patients.

Treatment:

Drug: Antivenom Serum

Procedure: Wound Debridement