Predictive Nature of Total Cholesterol Threshold: Possible Link to Suicidal Behavior

University Hospital Center (CHU)

Status: Unknown

Conditions: Current Major Depressive Disorder

Treatments: Other: patient's routine care

Study type: Interventional

Funder types: Other

Identifiers

NCT02847741

2011-A01657-34 (Other Identifier)

UF 8921

Details and patient eligibility

About

Suicidal behavior (SB) is a public health problem. The clinical model currently admitted to the understanding of SB is a stress vulnerability model, but so far, all scientific works has no clinical application. The management of psychiatric patients, including depressed subjects, faces the inability to detect those with a high risk of SB. Many studies have shown a link between low cholesterol and SB. A study has recently proposed a total cholesterol threshold below which the risk of suicide could be increased. However, a prospective study is needed to assess the predictive nature of such an indicator.

Full description

Investigators propose to assess, within a cohort of patients, the predictive value of a total cholesterol threshold in the occurrence of SB.

555 inpatients suffering from a current Major depressive disorder (MDD), hospitalized in the Department of Emergency Psychiatry and Post Acute Care will be recruited.

Each patient will attend a total of 5 visits during a follow-up period of 18 months (visits at 1, 3, 6, 12, and 18 months)

Enrollment: 555 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Major
• Meet the Diagnostic and Statistical Manual of Mental Disorders-IV (DSM) criteria for a major depressive episode
• Subject who signed the non-opposition form
• Able to understand the nature, purpose and methodology of the study
• Able to understand and perform the clinical and neuropsychological evaluations.

Exclusion criteria

• Subject whose primary psychiatric diagnosis is not a major depressive episode according to DSM-IV criteria (the existence of psychiatric comorbidity is not a criterion for non-inclusion)
• Refusal of participation
• Subject Deprived of liberty (by judicial or administrative decision)
• Subject protected by law (guardianship)
• Subject exclusion period in relation to another protocol
• Subject for which the maximum annual amount of allowances of € 4,500 has been reached
• Subject not affiliated to a social security scheme or not being the beneficiary of such a scheme.

Trial design

555 participants in 1 patient group

Major depressive episode

Other group

Description:

Depressive patients will be assessed by interview (psychiatrists), questionnaires and blood sampling, as the inpatients's routine care

Treatment:

Other: patient's routine care