Predictive Value of β2-microspheres for Postoperative Delirium

Southeast University

Status: Completed

Conditions: Postoperative Delirium

Study type: Observational

Funder types: Other

Identifiers

NCT03130231

199101026046

Details and patient eligibility

About

This study evaluated the predictive value of β2-microspheres for postoperative delirium (POD) in the elderly after orthopedic surgery. For this purpose, the levels of β2-microspheres in plasma and cerebrospinal fluid were compared between the POD and non-POD groups.

Full description

In this study, plasma and cerebrospinal fluid of the patients were collected to detect the levels of β2-microspheres before operation. Also, the patients were interviewed one day before the surgery and on postoperative days 1-3 by the Confusion Assessment Method and then divided them into POD and non-POD groups. The aim of the present study was to assess whether higher levels of β2-microspheres could predict the occurrence of POD.

Enrollment: 184 patients

Sex: All

Ages: 65+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• ≥65 years old, American Standards AssociationⅠ-Ⅲ, undergoing orthopedic operations under spinal anesthesia

Exclusion criteria

• decline to participate

Trial design

184 participants in 2 patient groups

POD group

Description:

POD group refers to the patients who were diagnosed to be delirious by the Confusion Assessment Method.

Non-POD group

Description:

Non-POD refered to the patients who did not become delirious by the Confusion Assessment Method.