Predictive Value of CEA and ctDNA in Lung Cancer Recurrence

Guangdong Provincial People's Hospital (Guangdong Provincial Academy of Medical Sciences)

Status: Not yet enrolling

Conditions: Lung Carcinoma

Study type: Observational

Funder types: Other

Identifiers

NCT07170046

KY2025-310

Details and patient eligibility

About

The study aims to investigate the predictive value of CEA levels for postoperative recurrence in the highly sensitive CEA lung cancer patients and to explore whether the dynamic changes of postoperative CEA and MRD in this population are related.This study was carried out to accurately predict the recurrence time, save the time and cost of changing the intervention strategy, and provide more personalized treatment for patients.

Full description

This study will collect two groups of cohorts: prospective and retrospective.

Enrollment: 100 estimated patients

Sex: All

Ages: 15 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Preoperative CEA > 5mg/l
2. MRD testing was conducted before the operation
3. The primary lesion was resected through surgery
4. There should be at least two CEA and MRD follow-up tests within 2 years after the operation
5. Postoperative pathology confirmed it as a malignant lung tumor

Exclusion criteria

1. Those without available imaging records
2. Patients with a history of malignant tumors within the past five years
3. Patients with secondary lung cancer

Trial design

100 participants in 2 patient groups

retrospective cohort

Description:

The clinical information of the population in this cohort was retrospectively collected.

prospective cohort

Description:

The clinical information of the population in this cohort was prospectively collected.