PREdictive Value of COntrast voluMe to creatinINe Clearance Ratio (PRECOMIN)

Guangdong Provincial People's Hospital (Guangdong Provincial Academy of Medical Sciences)

Status: Completed

Conditions: Contrast Induced Nephropathy

Study type: Observational

Funder types: Other

Identifiers

NCT01400295

20100917

Details and patient eligibility

About

To determine a relatively safe contrast media volume to creatinine clearance cut-off value to avoid contrast-induced nephropathy in patients following coronary angiography

Full description

Contrast media volume to creatinine clearance (V/CrCl) ratios were obtained from consecutive consenting patients after coronary angiography. Receiver-operator characteristic (ROC) curves were used to identify the optimal sensitivity for the observed range of V/CrCl. The predictive value of V/CrCl for the risk of contrast-induced nephropathy was assessed using multivariate logistic regression.Subgroup analysis was performed on patients with creatinine clearance < 60 ml/min,diabetes,emergent angiography.

Enrollment: 3,000 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients who agreed to stay in the hospital for 2-3 days after coronary angiography
• provided written informed consent

Exclusion criteria

• pregnancy
• lactation
• intravascular administration of an contrast medium within the previous seven days
• treatment with metformin,aminoglycosides,N-acetylcysteine (NAC),nonsteroidal anti-inflammatory drugs within the previous 48 h
• intake of nephrotoxic drugs within the previous seven days
• history of serious reactions to contrast mediums， severe concomitant disease renal transplantation , or end-stage renal disease necessitating dialysis
• patients who died during coronary angiography

Trial design

3,000 participants in 1 patient group

coronary angiography

Description:

The investigators reviewed all consecutive patients who were undergoing coronary angiography