Predictive Value of Doppler RSI for Prediction of AKI in Septic Patients in ICU

A

Ain Shams University

Status

Completed

Conditions

Acute Kidney Injury
Sepsis

Treatments

Diagnostic Test: Renal Doppler Ultrasound

Study type

Observational

Funder types

Other

Identifiers

NCT04426032
FMASU M S 299 / 2020

Details and patient eligibility

About

Acute kidney injury (AKI) Diagnosis is based on rising creatinine. Intrarenal vasoconstriction occurs earlier and measuring flow resistance in the renal circulation (Renal Resistive Index (RRI)) could become part of vital organ function assessment using Doppler ultrasound. The aim of this study is to predict AKI in septic patients in ICU by measuring RRI on admission by comparing two groups of patients, first group with RRI of normal value (0.6-0.7) and the other group with high RRI more than 0.7 and both with normal renal function on admission.

Full description

Patients who have criteria of sepsis, with normal renal function on admission will undergo Renal Doppler Ultrasound examination to measure Renal resistive index. Patients will be divided into 2 groups: Group (A) patients with renal resistive index between 0.6 and 0.7 (normal RRI). Group (B) patients with renal resistive index more than 0.7 (high RRI).

Enrollment

150 patients

Sex

All

Ages

18 to 60 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  1. Patients who have criteria of sepsis on admission which include two or more of SIRS which include: (Temperature >38°C or <36°C, Heart rate >90/min, Respiratory rate >20/min or PaCO2 <32mmHg (4.3kPa) and White blood cell count >12000/mm3 or <4000/mm3 or >10% immature bands.) in addition to suspected or confirmed infection.
  2. Patients who have normal renal function on admission.

Exclusion criteria

  1. Currently recovering from an AKI at the time of inclusion and Renal impairment on admission.
  2. Patients with obstructive renal failure, renal artery stenosis were excluded from this study.
  3. Patients on chemotherapy and/or radiotherapy.
  4. Pregnancy.

Trial design

150 participants in 2 patient groups

Patients with RRI between 0.6 and 0.7
Description:
Normal renal resistive index
Treatment:
Diagnostic Test: Renal Doppler Ultrasound
Patients with RRI more than 0.7
Description:
High renal resistive index
Treatment:
Diagnostic Test: Renal Doppler Ultrasound

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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