Predictive Value of Dynamic Combination of BNP and NGAL for the Prognosis of Patients With Sepsis

Southeast University, China

Status: Completed

Conditions: 28-day Mortality; Sepsis

Treatments: Other: BNP and NGAL

Study type: Interventional

Funder types: Other

Identifiers

NCT02871544

Zhongda Hospital AKI

Details and patient eligibility

About

Objective: to clarify the predictive value of brain natriuretic peptide (BNP) in combination with neutrophil gelatinase associated lipocalin (NGAL) for the prognosis of patients with sepsis.

Enrollment: 124 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age ≥18 years and <85 years;
• presence of severe sepsis according to Survival Sepsis Campaign 10;
• all patients voluntarily joined this study with informed consents.

Exclusion criteria

• participated in other trials within 30 days before the criteria for this trial were met;
• expected to die within 24 hours;
• pregnant;
• advanced malignancy with life expectancy <6 months;
• history of congestive heart failure;
• chronic renal dysfunction (baseline creatinine >176.8μmol/L); and
• relatives were unwilling to agree to the use of full life support.

Trial design

Primary purpose: Screening

Allocation: Non-Randomized

Interventional model: Factorial Assignment

Masking: None (Open label)

---

124 participants in 4 patient groups

Low BNP and Low NGAL Group

Sham Comparator group

Description:

BNP≤100pg/ml and NGAL≤153pg/ml

Treatment:

Other: BNP and NGAL

High BNP and Low NGAL Group

Active Comparator group

Description:

BNP\>100pg/ml and NGAL≤153pg/ml

Treatment:

Other: BNP and NGAL

Low BNP and High NGAL Group

Active Comparator group

Description:

BNP≤100pg/ml and NGAL\>153pg/ml

Treatment:

Other: BNP and NGAL

High BNP and High NGAL Group

Active Comparator group

Description:

BNP\>100pg/ml and NGAL\>153pg/ml

Treatment:

Other: BNP and NGAL